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Although the CNS is the major issue with ALS, the liver, spleen, and lungs are all impacted

Most patients reach their maintenance dose of 1.0 mg by week four, though some may continue escalating to 1.7 mg or 2.4 mg depending on their response and tolerance

Tronnier M, Rudolph P, Koser T, Raasch B, Brinckmann J

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